Health is a unity and harmony within the mind, body and spirit which is unique to each person, and is as defined by that person. The level of wellness or health is, in part, determined by the ability to deal with and defend against stress. Health is determined by physiological, psychological, socio-cultural, spiritual, and developmental stage variables.
Despite different triggers of disease, all roads lead to lupus
Lupus :: Despite different triggers of disease, all roads lead to lupus
Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease in which the immune system attacks the body?s cells and tissues.In a study appearing online on July 19 in advance of publication in the August print issue of the Journal of Clinical Investigation, Chandra Mohan and colleagues from UT Southwestern Medical Center examined different strains of lupus-prone mice in order to address this question.
They report that different signaling pathways are upregulated in lupus B cells as the disease evolves. However, the very same pathways are shown to be upregulated in B cells from mice with different lupus-prone genetic backgrounds, indicating that although the genetic trigger of the disease may differ, these different triggers ultimately converge upon a shared set of signaling pathways to induce disease. Finally, the authors were able to treat lupus in these animals using a derivative of the drug rapamycin, thereby identifying one of these pathways (involving the molecules known as AKT and mTOR) as being an attractive therapeutic target in lupus.
TITLE: Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus
(Lupus :: Despite different triggers of disease, all roads lead to lupus published at SpiritIndia on Saturday, July 21, 2007)
Lupus
Search more information on Lupus, Lupus booksRecently posted related articles on Lupus :
- Lupus :: Immunosuppressive drug effective for reducing lupus flares
- Lupus :: Research suggests targeted treatment strategies for lupus
- Lupus :: Existing drugs show promise for treating end-stage renal disease in lupus
- Lupus :: Patients, Physicians Invited to Lupus Education Day
- Lupus :: Gene linked to Lupus
- Lupus :: Preclinical study suggests organ-transplant drug may aid in lupus fight
- Lupus :: Controlling stress helps fight chronic diseases such as lupus
- Lupus :: Research links genetic mutations to lupus
- Lupus :: Despite different triggers of disease, all roads lead to lupus
- Sperm :: Sperm abnormalities seen in male lupus patients
Most related articles:
- Lupus :: Despite different triggers of disease, all roads lead to lupus- Lupus :: Gene linked to Lupus - 17.9
- Lupus :: Abnormal pap smears in women with lupus - 16.1
- Systemic Lupus Erythematosus :: Interferon-regulated chemokines and SLE - 15.4
- Lupus :: Preclinical study suggests organ-transplant drug may aid in lupus fight - 14.8
- Lupus :: Bio-Tech Company Conquers Lupus - 13.8
- Lupus :: Genelabs for additional trial of lupus drug Prestara - 13.5
- Lupus :: Epigenetic code n patients with systemic lupus erythematosus - 13.2
- Lupus :: Cancer Drug Rituximab Fights Lupus - 13.2
- Lupus :: Mirac stops the proliferation of cells that cause Lupus - 13
Lupus - recent related articles/news stories:
- Lupus drug Benlysta effective for SLE patients- Genes linked with lupus giving hope for new treatments
»» Heart Disease :: ERK1/2 at root of congenital heart disease in Noonan syndrome
«« Depression :: Sanofi obesity pill Acomplia not be used in patients on antidepressants or with depression
The information provided on SpiritIndia.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Spirit India comply with the HONcode principles for trustworthy health information.
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com