Health is a unity and harmony within the mind, body and spirit which is unique to each person, and is as defined by that person. The level of wellness or health is, in part, determined by the ability to deal with and defend against stress. Health is determined by physiological, psychological, socio-cultural, spiritual, and developmental stage variables.
Drug-eluting stent controversy explored in the American Heart Hospital Journal
Stent :: Drug-eluting stent controversy explored in the American Heart Hospital Journal
The Summer 2007 issue of the American Heart Hospital Journal explores one of the pivotal issues in cardiology today, the drug-eluting stent. Through commentaries from 10 leading national and international specialists, the issue presents a comprehensive discussion on the explosive growth and the potential risks of DESs.Dr. Ulrich Sigwart of University Hospital in Geneva, Switzerland, author of one of the studies, examines the sobering current appraisal of DES use, in contrast to the triumphs of their early success. ?Subacute stent thrombosis due to incomplete intimal coverage, the formation of blood clots that can occur when the inner layers of blood vessels are not fully treated, remains the Achilles? heel of DES use,? says Dr. Sigwart. ?The polymer matrix used for the delivery of drugs, which clearly induces inflammatory responses, may, in part, be responsible for very late thrombosis.?
Dr. Renu Virmani and colleagues at the CVPath Institute of Gaithersburg, Maryland base the judgments in their article on the evidence obtained through pathologic studies of patients dying after stent implantation. ?These data indicate that DESs cause both substantial impairment in arterial healing characterized by lack of complete re-endothlialization (the re-healing of the inner surfaces of vessels after stenting) and persistence of fibrin, a protein that indicates blood clotting, when compared with bare metal stents. This delayed healing is the primary substrate underlying all cases of late DES thrombosis at autopsy.?
In contrast, Drs. Williams and Abbott, of Brown Medical School and affiliated with Rhode Island Hospital, note, ?DESs are a revolutionary advancement in interventional cardiology and are here to stay. Recognizing that they are different from bare metal stents, it is prudent to exercise caution with these devices and avoid using them in patients in whom dual antiplatelet therapy, a common practice used to reduce blood clotting, is unlikely or impossible.?
Dr. Peter Fitzgerald of Stanford University Medical Center, who writes with his colleagues, Drs. Shimohama and Honda of the Center for Cardiovascular Technology, offers his view of the future of DESs. ?While first generation DESs place great emphasis on efficacy, long-term safety issues have arisen, making DESs stand in an exquisite balance among occasionally conflicting effects. Careful reexamination of research findings, as well as redefinition of safe and effective outcomes, will lead future stent technology in the optimal direction.?
(Stent :: Drug-eluting stent controversy explored in the American Heart Hospital Journal published at SpiritIndia on Thursday, August 9, 2007)
Stent
Search more information on Stent, Stent booksRecently posted related articles on Stent :
- Stent :: Horizons AMI trial data to be presented at TCT 2007
- Stent :: Drug coated heart stents safe
- Stent :: Drug eluting stents & bare metal stents yield similarly low mortality rates
- Stent :: Drug coated stents raises risks in heart attack patients
- Stent :: Nanowire coating for bone implants, stents
- Stent :: Drug-eluting stent controversy explored in the American Heart Hospital Journal
- Stent :: Modified herpes virus keeps arteries free-flowing following angioplasty or stent placement
- Stent :: FDA approves ostial pro stent positioning system
- Stent :: New method of coating stents for keeping blood vessels open
- Stent :: Study finds drug-coated stents safe for coronary artery blockages
Most related articles:
- Stent :: Drug-eluting stent controversy explored in the American Heart Hospital Journal- Stent :: Cypher Coronary stents approved for use by Health Canada - 23.1
- Stent :: FDA probes safety of popular heart stent - 22.4
- Stent :: Stent users need blood thinners, antiplatelet medications - 20.5
- Stent :: Answering Questions About Drug-Eluting Stents - 19.2
- Stent :: Drug coated stents - higher clot risk - 18.4
- Stent :: Second generation drug-eluting stent system challenges current gold standard - 17.5
- Stent :: Boston Scientific Announces Japanese Launch of TAXUS Express2 Coronary Stent System - 17.3
- Stent :: ENDEAVOR III Trial reports key findings on new-generation stent - 17.2
- Stent :: NEJM articles on drug-eluting stents welcomed - 16.9
Stent - recent related articles/news stories:
- Certain drug coated stents may be safe, effective- Cognitive behavior therapy better for insomnia treatment
- Sleep may be factor in weight control, BMI
- Drug eluting stents prove more effective
- Insomnia appears to be a persistent condition
»» Obesity :: Obesity linked to hyperparathyroidism in chronic kidney disease
«« Thyroid :: Role of thyroid hormones in slumber under investigation at Rutgers
The information provided on SpiritIndia.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Spirit India comply with the HONcode principles for trustworthy health information.
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com