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Preclinical study suggests organ-transplant drug may aid in lupus fight
Lupus :: Preclinical study suggests organ-transplant drug may aid in lupus fight
A compound related to a drug used in humans to prevent organ-transplant rejection attacks a key biochemical process in the faulty immune cells of lupus-prone mice, suggesting a possible new approach to combating the disease, UT Southwestern Medical Center researchers have found.Lupus is a chronic autoimmune disease in which the immune system attacks the body?s cells and tissues. In a normal immune system, foreign intruders are recognized by special immune cells called B-cells, which produce antibodies. In patients with lupus, however, the antibodies created by the B-cells start to attack the body itself.
Certain genetic strains of mice are prone to developing lupus. In the current study, a research team led by Dr. Mohan discovered that an analog of rapamycin shuts down specific biochemical processes in the B-cells of the mice. Rapamycin has been used in humans to prevent organ transplant rejection and for treating cancer. The analog of rapamycin halted production of antibodies and the development of lupus in all the strains of lupus-prone mice, as well as improved symptoms, despite each animal having a different genetic makeup that led to the disease.
?Though lupus in different mouse models may originate from different genetic triggers, those triggers ultimately funnel through a shared series of biochemical pathways that lead to the disease,? Dr. Mohan said. ?These shared biochemical pathways represent an attractive target for future therapeutic intervention in lupus patients.?
In humans, lupus can cause life-threatening damage to the kidneys, lungs, heart, central nervous system, joints, blood vessels and skin. It can be associated with severe fatigue, joint pain, skin rashes, hair loss and neurological problems. Although treatable symptomatically, there is currently no cure for the disease, which affects up to 1 million people in the U.S.
(Lupus :: Preclinical study suggests organ-transplant drug may aid in lupus fight published at SpiritIndia on Thursday, August 16, 2007)
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