A brain tumor is any mass created by an abnormal and uncontrolled growth of cells either found in the brain (neurons, glial cells, epithelial cells, myelin producing cells, etc.) or spread from elsewhere (metastasis). Brain tumors are usually located in the posterior third of the brain in childhood and in the anterior two-thirds of the brain in adulthood.
Long-term effects of pediatric brain tumors and treatment
Brain Tumor :: Long-term effects of pediatric brain tumors and treatment
A team of researchers from Emory and Georgia State Universities has been awarded a four-year, nearly $850,000 grant from the American Cancer Society to study risk factors for long-term social and cognitive problems in adult survivors of pediatric brain tumors.The research team will use cutting-edge neuroimaging technology and neuropsychological evaluations to look for neurological, cognitive and psychosocial predictors of adaptive functioning--the skills needed to live independently. The hypothesized predictive markers include memory, decision-making skills, socioeconomic status as well as the structure and integrity of the brain's white matter.
"Identifying these predictors will allow for early recognition of individuals at risk for adverse long-term outcomes, leading to the development of interventions that lessen the severity of late effects of the treatment of brain tumors and optimizing the adaptive functioning across the patient's lifespan," says Hui Mao, PhD, assistant professor of radiology in Emory University School of Medicine and the lead investigator of the study at Emory.
The research team includes a neurologist, neuro-oncologist, neuropsychologists and radiologists. The researchers will use functional magnetic resonance imaging (fMRI) to map the brain regions where executive function abilities such as working memory are processed and how they may be altered by the presence of a tumor and subsequent radiation or chemotherapy treatments.
Diffusion tensor imaging (DTI) will allow the researchers a look at the integrity and arrangement of the brain's white matter, the complex network of neuronal fibers that connect different areas of the brain and that are often affected by tumors themselves as well as treatments.
Brain tumors are the second most common type of pediatric cancer, exceeded only by childhood leukemia. Because long-term survival rates of pediatric brain-tumor patients have risen by more than one-third over the last 20 years, researchers say new studies on the long-term effect and outcomes of individuals following treatment of brain tumors are needed to help recognize markers of later adaptive functioning and develop therapeutic interventions to reduce overall levels of disability and improve the quality of life in this growing population. Studies have shown lower rates of employment, academic achievement and marriage in brain tumor survivors relative to the comparison groups, and higher rates of depression and alcoholism. Likewise, neurological and cognitive difficulties may include hearing and vision loss, motor impairment and learning difficulties.
"This new study aims to gain insights into brain structural and functional changes caused by the tumor and their links to those outcomes, and we hope that the new information and understanding will also help us to improve the current strategy of brain tumor treatment," says Dr. Mao.
(Brain Tumor :: Long-term effects of pediatric brain tumors and treatment published at SpiritIndia on Monday, August 20, 2007)
Brain Tumor
Search more information on Brain Tumor, Brain Tumor booksRecently posted related articles on Brain Tumor :
- Brain Tumor :: Customized virus kills brain tumor stem cells that drive lethal cancer
- Brain Tumor :: Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
- Brain Tumor :: Long-term effects of pediatric brain tumors and treatment
- Brain Tumor :: Invasion of the brain tumors
- Brain Tumor :: Brain discovery could fight deadly tumors
- Brain :: MIT IDs link between brain tumor proteins
- Brain Tumor :: First report on how children with brain tumors perform at school
- Brain Tumor :: A genetic factor predicts prognosis in brain tumor patients
- Chemotherapy :: Chemotherapy may enhance the effectiveness of brain tumor vaccines
- Brain Tumor :: Chemotherapy drug shrinks brain tumors
Most related articles:
- Brain Tumor :: Long-term effects of pediatric brain tumors and treatment- Brain :: Virus targets brain cancer stem cells - 15
- Brain Tumor :: To celebrate brain tumor awareness week - 12.6
- Brain Tumor :: Chemotherapy drug shrinks brain tumors - 11.6
- Brain Tumor :: Brain tumors arise from cancer stem cells - 11.3
- Brain :: NIH funding UIC brain tumor research - 11.2
- Brain Tumor :: NIH Funding UIC Brain Tumor Research - 10.9
- Brain Cancer :: Researchers study effects of Aricept in pediatric brain cancer survivors - 10.8
- Brain Tumor :: First report on how children with brain tumors perform at school - 10.8
- Brain Tumor :: Brain tumors may originate with neural stem cells - 10.5
Brain Tumor - recent related articles/news stories:
- Altered genes play role in development of brain tumors- Avastin approved for brain cancer Glioblastoma
- Scorpion venom with nanoparticles slows brain cancer spread
- Gene mutations cause childhood brain cancer medulloblastoma
- Brain cancer malignant glioma linked to gene mutations
»» Cancer :: Allergic reaction to cancer drug in the middle Southern US
«« Psychology :: Girls prefer pink, or at least a redder shade of blue
The information provided on SpiritIndia.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Spirit India comply with the HONcode principles for trustworthy health information.
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com