The prostate is a gland that is part of male mammalian sex organs. Its main function is to secrete and store a clear, slightly basic fluid that is part of semen. A healthy human prostate is approximately the size of a walnut. It surrounds the urethra just below the urinary bladder.
Combination therapy with Avodart & tamsulosin improves enlarged prostate BPH
Prostate :: Combination therapy with Avodart & tamsulosin improves enlarged prostate BPH
GlaxoSmithKline announced new results from a large study that demonstrate combination treatment with Avodart® (dutasteride) and the alpha blocker, tamsulosin, provides significantly greater urinary symptom improvement for men with enlarged prostate than either Avodart or tamsulosin monotherapy over 24 months.In addition, one of the CombAT analyses, which was conducted post-hoc, showed that Avodart provides a pattern of increasing enlarged prostate symptom improvement over 24 months. Tamsulosin — the most commonly prescribed medicine for the condition — showed a plateau in symptom improvement1 from month three through 24. Common symptoms of enlarged prostate include frequent urge to urinate or difficulty emptying the bladder.
The CombAT study includes 4,800 men (combination therapy, n=1492; Avodart, n=1502; tamsulosin, n=1519) with moderate-to-severe enlarged prostate symptoms. All study participants received placebo for four weeks and then were randomized to receive Avodart and tamsulosin combination therapy, Avodart monotherapy or tamsulosin monotherapy.1,2
Enlarged prostate, also known as benign prostatic hyperplasia (BPH), is a condition that affects 50 per cent of men over the age of 50 and more than 90 per cent of men over age 80.3 Avodart belongs to a class of medicines known as 5 alpha reductase inhibitors (5 ARIs), which shrink the prostate over time. Tamsulosin is an alpha blocker, a class of medicines that relaxes muscles in the bladder and prostate.4
“This trial suggests that physicians should consider combining Avodart and tamsulosin as initial therapy to achieve improved symptom relief for men with enlarged prostate,” said Professor Claus Roehrborn, from the Universityof Texas, who presented the new data. “This study provides important new data to guide medical therapy for men with symptomatic BPH.”
(Prostate :: Combination therapy with Avodart & tamsulosin improves enlarged prostate BPH published at SpiritIndia on Saturday, September 15, 2007)
Prostate
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