Health is a unity and harmony within the mind, body and spirit which is unique to each person, and is as defined by that person. The level of wellness or health is, in part, determined by the ability to deal with and defend against stress. Health is determined by physiological, psychological, socio-cultural, spiritual, and developmental stage variables.
Combination therapy reverses effects of portal hypertension in rats
Liver :: Combination therapy reverses effects of portal hypertension in rats
A combined treatment with rapamycin and Gleevec might reverse the effects of portal hypertension in patients with chronic liver disease, according to the results of a new study on rats.Portal hypertension is a serious complication of chronic liver disease, and a leading cause of liver transplantation and mortality. It develops when a blockage in the blood flow through the liver causes the body to develop new blood vessels to develop (through a process called angiogenesis) across the esophagus and stomach. These new vessels drain into the portal vein, worsening the portal blood pressure and contributing to the formation of life-threatening complications like esophageal varices. Prior studies have suggested that anti-angiogenic treatment might help prevent the progression of the portal hypertension syndrome.
Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) are crucial to angiogenesis, so researchers, led by Mercedes Fernandez of the IDIBAPS in Barcelona, examined the effects of VEGF and PDGF inhibitory drugs on rats with established portal hypertension, to best mimic the typical human patient. They treated portal vein-ligated rats with rapamycin (VEGF signaling inhibitor), Gleevec (PDGF signaling inhibitor) or both simultaneously, and determined the effects on hyperdynamic splanchnic circulation and portosystemic collateralization.
In rats whose portal hypertension was fully developed, the combined therapy significantly reduced splanchnic neovascularization and pericyte coverage of neovessels. The rats experienced a 40 percent decrease in portal pressure, along with a 30 opercent decrease in superior mesenteric artery blood flow and a 63 percent increase in superior mesenteric artery resistance. This was “a significant reversal of the hemodynamic changes provoked by portal hypertension in rats,” the authors report.
They found that the magnitude of the effects of the combination treatment was superior to the addition of the effects of either drug alone, suggesting that the two worked together to mediate the maintenance of the vascular and circulatory abnormalities observed in rats with portal hypertension.
This is the first study to show that portal hypertension development is associated with a progressive overexpression of PDGF as well as VEGF. It also revealed that anti-angiogenic therapy could not merely prevent, but also revert, abnormalities associated with portal hypertension which would be a very helpful for treating patients with portal hypertension, because they are typically only diagnosed when their condition causes clinical problems. Furthermore, both drugs tested in this study have already been broadly used to treat human malignancies.
“Our results provide new insights into how angiogenesis regulates portal hypertension by demonstrating that the maintenance of increased portal pressure, hyperkinetic circulation, splanchic neovascularization and portosystemic collaterization is regulated by VEGF and PDGF in portal hypertensive rats,” the authors conclude. “An extended anti-angiogenic strategy (i.e. targeting VEGF/endothelium and PDGF/pericytes) may represent a novel approach in the treatment of portal hypertension.”
(Liver :: Combination therapy reverses effects of portal hypertension in rats published at SpiritIndia on Monday, October 1, 2007)
Liver
Search more information on Liver, Liver booksRecently posted related articles on Liver :
- Liver Cancer :: Nexavar approved for patients with inoperable liver cancer
- Hepatitis B :: Decrease in Liver Transplant in Patients with Hepatitis B
- Liver :: Endosonography-guided biliary drainage is useful in cases with failed endoscopic biliary stenting
- Liver :: Plasma serotonin levels can correlate with degree of liver insufficiency
- Liver Cancer :: Radio waves fire up nanotubes embedded in tumors, destroying liver cancer
- Liver :: A new chemotherapeutic target for hepatocellular carcinoma
- Liver :: Liver fibrosis will be treated by a potential target
- Liver :: Patients over age 60 do well after liver transplantation
- Liver :: Combination therapy reverses effects of portal hypertension in rats
- Liver :: Noninvasive tests for cirrhosis may help to avoid liver biopsy
Most related articles:
- Liver :: Combination therapy reverses effects of portal hypertension in rats- Portal Hypertension :: Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension - 12.2
- Liver :: Liver stiffness indicates portal hypertension - 11.1
- Hypertension :: Garlic helpful in lung condition - Pulmonary hypertension - 9.5
- Liver :: New Mayo Clinic MRI technology enables noninvasive liver diagnoses - 8.9
- Cirrhosis :: Racial disparities in treatment of patients with cirrhosis and complications of portal hypertension - 8.7
- Cirrhosis :: Preventing variceal bleeding - 8.2
- Stem Cell :: Stem cells speed growth of healthy liver tissue - 8.1
- Blood Pressure :: Specific antagonism lowers blood pressure - 8
- Hypertension :: Combination for Blood Pressure Control in hypertensive patients - 7.7
Liver - recent related articles/news stories:
- Microneedle patch would replace injections and needles- Anesthesia during delivery does not affect learning in baby
- Internet based intervention improves insomnia
- iPhone 3GS is winning, says Apple CEO Steve Jobs
- New gene silencing way to turn off cervical cancer genes
»» Insulin :: Botched production of insulin molecule may lead to diabetes
«« Hepatitis C :: Weight-based dosing of ribavirin improves outcomes for patients with hepatitis C
The information provided on SpiritIndia.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Spirit India comply with the HONcode principles for trustworthy health information.
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com