Health is a unity and harmony within the mind, body and spirit which is unique to each person, and is as defined by that person. The level of wellness or health is, in part, determined by the ability to deal with and defend against stress. Health is determined by physiological, psychological, socio-cultural, spiritual, and developmental stage variables.
Liver fibrosis will be treated by a potential target
Liver :: Liver fibrosis will be treated by a potential target
The outcome of hepatitis is either self recovery or its development into liver fibrosis or, further, liver cirrhosis. Liver fibrosis is the early pathological process of cirrhosis, which is considered a reversible, wound-healing response. Since no ideal drug is available for its therapy, liver fibrosis is currently considered to be a major worldwide health problem.A research article published on November 7 in the World Journal of Gastroenterology addresses this question. A research team led by Dr. ZH Liu from Jilin University spent more than five years researching ARIP2. The researchers used mouse Hepal-6 cells obtained from mouse a hepatoma cell line that had functions of hepatic parenchymal cells to investigate the effects of ARIP2 anti-fibrosis on the production of collagen type IV, which is a component of the extracellular matrix (ECM) in liver fibrosis.
One conclusion reported by the investigators is that the mode of expression regulation by various activators of signaling transduction, such as PMA, foskolin and LPS, has been characterized, and its negative effect on the production of collagen type IV revealed, using Hepal-6 cells.
An additional result was that the expression level of ARIP2 mRNA in the Hapel-6 cells was elevated 12 h after treatment with activin A and endotoxin LPS. Thus, it was concluded that ARIP2 participates in the negative feedback regulation of signal transduction in the late stage by affecting the expression of ActRIIA, which further suggests that ARIP2 might be a potential target for treatment of liver fibrosis induced by activin.
(Liver :: Liver fibrosis will be treated by a potential target published at SpiritIndia on Wednesday, October 17, 2007)
Liver
Search more information on Liver, Liver booksRecently posted related articles on Liver :
- Liver Cancer :: Nexavar approved for patients with inoperable liver cancer
- Hepatitis B :: Decrease in Liver Transplant in Patients with Hepatitis B
- Liver :: Endosonography-guided biliary drainage is useful in cases with failed endoscopic biliary stenting
- Liver :: Plasma serotonin levels can correlate with degree of liver insufficiency
- Liver Cancer :: Radio waves fire up nanotubes embedded in tumors, destroying liver cancer
- Liver :: A new chemotherapeutic target for hepatocellular carcinoma
- Liver :: Liver fibrosis will be treated by a potential target
- Liver :: Patients over age 60 do well after liver transplantation
- Liver :: Combination therapy reverses effects of portal hypertension in rats
- Liver :: Noninvasive tests for cirrhosis may help to avoid liver biopsy
Most related articles:
- Liver :: Liver fibrosis will be treated by a potential target- Liver :: A new index for measuring liver fibrosis - 12.4
- Liver :: New way to predict advanced fibrosis in patients with nonalcoholic fatty liver disease - 12
- Liver :: New Mayo Clinic MRI technology enables noninvasive liver diagnoses - 11.8
- Liver Failure :: New bio-artificial liver may increase survival rates for liver failure - 10.9
- Hepatitis :: New treatment for Chronic Hepatitis B - 10.8
- Liver :: Inhaling helps heal liver transplant recipients - 10.6
- Hepatitis C :: Use of Hepatitis C-Infected Donors in Liver Transplantation - 10.5
- Liver :: Noninvasive tests for cirrhosis may help to avoid liver biopsy - 10
- Hepatitis :: Liver disease - Hepatitis - 9.8
Liver - recent related articles/news stories:
- Microneedle patch would replace injections and needles- Anesthesia during delivery does not affect learning in baby
- Internet based intervention improves insomnia
- iPhone 3GS is winning, says Apple CEO Steve Jobs
- New gene silencing way to turn off cervical cancer genes
»» HIV :: A low prevalence of H pylori in HIV-positive patients
«« Osteoporosis :: New research on structure of bones raises questions for treatment of osteoporosis
The information provided on SpiritIndia.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Spirit India comply with the HONcode principles for trustworthy health information.
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com
Health, Business, Science, Sports, Entertainment, Technology
©2002-2009 SpiritIndia.com